Kreiman AN, Garner SE*, Carroll SC, Sutherland MC. Biochemical mapping reveals a conserved heme transport mechanism via CcmCD in System I bacterial cytochrome c biogenesis. 2025. mBio. Apr 1:e03515-24. doi: https://doi.org/10.1128/mbio.03515-24. Epub ahead of print. PMID: 40167305
Yeasmin T, Carroll SC, Hawtof DH*, Sutherland MC. Helicobacter pylori and Campylobacter jejuni bacterial holocytochrome c synthase structure-function analysis reveals conservation of heme binding. 2024. Communications Biology. 7(1):984. PMID: 39138305; PMCID: PMC11322641. doi: 10.1038/s42003-024-06688-3.
Kreiman AN+, Yeasmin T+, Sutherland MC. Recombinant Biogenesis and Analysis of Cytochrome c Species. 2024. Methods Mol Biol. 2839:195-211. PMID: 39008254. doi: 10.1007/978-1-0716-4043-2_10. +co-first authors, contributed equally.
Grunow AL+, Carroll SC+, Kreiman AN, Sutherland MC. Structure-function analysis of the heme-binding WWD domain in the bacterial holocytochrome c synthase, CcmFH. 2023. mBio. 2023 mBio 14:e01509-23. PMID: 37929956; PMCID: PMC10746174. doi: 10.1128/mbio.01509-23. +co-first authors, contributed equally.
Mendez DM, Lowder EP*, Tillman DE*, Sutherland MC, Collier AL, Rau MJ, Fitzpatrick JAJ, Kranz RG. 2022. Cryo-EM of CcsBA reveals the basis for cytochrome c biogenesis and heme transport. Nature Chemical Biology: 18, 101-108. PMID: 34931065. PMCID:PMC8712405. DOI: 10.1038/s41589-021-00935-y
Sutherland MC^+, Mendez DM+, Babbitt SE+, Tillman DE*, Melnikov O, Tran NL, Prizant NT, Collier AS, Kranz RG. 2021^. In vitro reconstitution reveals major differences between human and bacterial cytochrome c synthases. eLife: 10:e64891. DOI: 10.7554/eLife.64891. ^co-corresponding authors, +co-first authors.
- Selected for an eLife Digest – “The heme connection” https://elifesciences.org/digests/64891/the-heme-connection
- Highlighted in Science Editor’s Choice “This week in science” – Protein Biogenesis, Targeting heme insertion. Science. 2021. 372(6547):p1164. https://science.sciencemag.org/content/372/6547/twil
- Spotlight in Trends in Molecular Medicine – Prospective antibacterial inhibition of c-type cytochrome synthesis. Trends in Molecular Medicine. 2021. (27)10:928-930. https://www.sciencedirect.com/science/article/abs/pii/S147149142100188X?via%3Dihub
- Highlighted by Washington University in St. Louis THE SOURCE – “Heme is not just for Impossible Burgers” – https://source.wustl.edu/2021/05/heme-is-not-just-for-impossible-burgers/
Keffer JL, McAllister SM, Garber AI, Hallahan BJ, Sutherland MC, Rozovsky S, Chan CS. 2021. Iron oxidation by a fused cytochrome-porin common to diverse iron-oxidizing bacteria. mBio: 12:e01074-21. PMID: 34311573. DOI: 10.1128/mBio.01074-21
Gupta D, Sutherland MC, Rengasamy K, Meacham JM, Kranz RG, Bose A. Photoferrotrophs Produce a PioAB Electron Conduit for Extracellular Electron Uptake. mBio. 2019 Nov 5;10(6). pii: e02668-19. doi: 10.1128/mBio.02668-19.
Sutherland MC, Tran NL*, Tillman DE*, Jarodsky JM, Yuan J, Kranz RG. 2018. Structure-Function Analysis of the Bifunctional CcsBA Heme Exporter and Cytochrome c Synthetase. mBio: 9(6). pii: e02134-18. doi: 10.1128/mBio.02134-18.
Sutherland MC, Jarodsky JM, Ovchinnikov S, Baker D, Kranz RG. 2018. Structurally Mapping Endogenous Heme in the CcmCDE Membrane Complex for Cytochrome c Biogenesis. J Mol Biol: 430(8):1065-1080. doi: 10.1016/j.jmb.2018.01.022.
- Commentary:Yuan X, Hamza I. 2018. Cys Links Heme: Stereo-orientation of Heme Transfer in Cytochrome c Biogenesis. J Mol Biol: 430(8):1081–1083. doi:10.1016/j.jmb.2018.02.021
Sutherland MC, Rankin JA, Kranz RG. 2016. Heme Trafficking and Modifications during System I Cytochrome c Biogenesis: Insights from Heme Redox Potentials of Ccm Proteins. Biochemistry: 55(22):3150-6. doi: 10.1021/acs.biochem.6b00427.
Babbitt SE, Sutherland MC, San Francisco B, Mendez DL, Kranz RG. 2015. Mitochondrial cytochrome c biogenesis: no longer an enigma. Trends Biochem Sci: 40(8):446-55. doi: 10.1016/j.tibs.2015.05.006.
Jeong KC, Sutherland MC, Vogel JP. 2015. Novel export control of a Legionella Dot/Icm substrate is mediated by dual, independent signal sequences. Mol Microbiol: 96(1):175-88. doi: 10.1111/mmi.12928.
San Francisco B, Sutherland MC, Kranz RG. 2014. The CcmFH complex is the system I holocytochrome c synthetase: engineering cytochrome c maturation independent of CcmABCDE. Mol Microbiol: 91(5):996-1008. doi: 10.1111/mmi.12510.
Sutherland MC, Binder KA*, Cualing PY*, Vogel JP. 2013. Reassessing the role of DotF in the Legionella pneumophila type IV secretion system. PLoS One: 8(6):e65529. doi: 10.1371/journal.pone.0065529.
Sutherland MC, Nguyen TL*, Tseng V*, Vogel JP. 2012. The Legionella IcmSW complex directly interacts with DotL to mediate translocation of adaptor-dependent substrates. PLoS Pathog: 8(9):e1002910. doi: 10.1371/journal.ppat.1002910.
Sutherland MC, Vogel JP. 2012. Reclamation of ampicillin sensitivity for the genetic manipulation of Legionella pneumophila. Appl Environ Microbiol: 78(15):5457-9. doi: 10.1128/AEM.00669-12.
Vincent CD, Friedman JR, Jeong KC, Sutherland MC, Vogel JP. 2012. Identification of the DotL coupling protein subcomplex of the Legionella Dot/Icm type IV secretion system. Mol Microbiol: 85(2):378-91. doi: 10.1111/j.1365-2958.2012.08118.x.
*denotes undergraduate researcher